United finished second last season and have recruited heavily in a bid to bridge the gap to Manchester City. The Red Devils have signed Jadon Sancho and Raphael Varane, but the Frenchman will not feature on opening day.
United will also be without the services of Marcus Rashford and Edinson Cavani, which means Mason Greenwood could get a start.
Leeds, meanwhile, will look to build on their ninth-place finish from last season. Kalvin Phillips will miss this fixture after his late return from the Euros, while Diego Llorente is also unavailable.
Manchester United vs Leeds United
Old Trafford, Manchester
14 Aug 2021, 5:00 pm
MUN vs LU Dream11 Team Prediction
Manchester United: De Gea; Shaw, Maguire, Lindelöf, Wan-Bissaka; Pogba, Matic, Fernandes; James, Martial, Greenwood
Leeds United: Meslier; Cooper, Struijk, Ayling, Dallas; Harrison, Klich, Koch; Rodrigo, Raphinha, Bamford
MUN vs LU Dream11 Captain and Top Picks
MUN vs LU Dream11 Team Today
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